What is the role of mitochondrial ROS in neutrophil-mediated inflammation and autoimmunity?

Dr Christian Lood from the University of Washington, USA was invited by the scientific committee of Targeting Mitochondria Congress to present his recent data related to the role of mitochondrial ROS in neutrophil-mediated inflammation and autoimmunity.

Marvin Edeas and Volkmar Weissig, chairmen of the conference, stated: "Dr Lood will present some of the recent data on the role of mitochondria in neutrophil-mediated inflammation and autoimmunity. In particular, he will highlight the following points:

- role of mitochondrial ROS in induction of neutrophil programmed necrosis, neutrophil extracellular trap (NET) formation, and its implications in autoimmunity such as vasculitis and systemic lupus erythematosus (SLE)

- how released mitochondrial DNA may confer inflammation through the recently described DNA-sensing cGAS-STING pathway

- description of some potential approaches to limit mitochondrial-mediated damage in SLE"

If you are interested to know more about mitochondria, inflammation and autoimmunity, don't hesitate to register to Targeting Mitochondria 2016: www.targeting-mitochondria.com

Marvin Edeas / Volkmar Weissig / Chairmen of WMS