How to utilize a human hepatoma cell line to study off-target effects of drugs on mitochondrial DNA maintenance and bioenergetics?

The next 9th World Congress on Targeting Mitochondria, will welcome Dr Matthew J. Young from SIU School of Medicine in Carbondale, USA to talk about “Utilizing a human hepatoma cell line to study off-target effects of drugs on mitochondrial DNA maintenance and bioenergetics”.

According to Dr Young: "Evidence suggests anti-HIV nucleoside reverse transcriptase inhibitors (NRTIs) block the DNA synthesis activity of human DNA polymerases localized to mitochondria. Mitochondrial DNA (mtDNA) maintenance is important as mtDNA damage can induce cell death. Recently, NRTI drugs have been proposed to have anti-cancer properties. We are currently using a human hepatoma-derived cell line to investigate effects of drugs on cellular viability, bioenergetics, and mtDNA maintenance”.

Targeting Mitochondria 2018
October 23-25, 2018 - Berlin, Germany
www.targeting-mitochondria.com