Foxp3 increases oxidative phosphorylation and Nad oxidation, adapting regulatory T cells to low glucose high lactate environments

Dr. Alessia Angelin from Children's Hospital of Philadelphia, Philadelphia, USA  will give presentation about "Foxp3 increases oxidative phosphorylation and Nad oxidation, adapting regulatory T cells to low glucose high lactate environments"  during the 9th World Congress on Targeting Mitochondria, which will be held at Steigenberger Hotel, Berlin on October 23-25, 2018.

Dr. Alessia Angelin highlights her research as: "T-regulatory (Treg) cells maintain peripheral tolerance and prevent autoimmunity, but their immune suppressive properties can also work to a disadvantage in the tumor microenvironment. Solid tumors can be depleted of glucose and enriched with lactic acid. This can weaken anti-tumor immunity, as cytotoxic and effector T cells require glycolysis to proliferate and produce cytokines."

For more information about Targeting Mitochondria 2018, www.targeting-mitochondria.com