Mitochondrial DNA in cancer: The overlooked oncogenome

Targeting Mitochondria 2021 Payam Gammage

Dr. Payam A. Gammage from CRUK Beatson Institute, United Kingdom will join the Targeting Mitochondria 2021 congress and will present a talk entitled Mitochondrial DNA in cancer: the overlooked oncogenome  during the congress.

Summary of talk: Mutations of mtDNA have been detected in human cancers for some decades, although their impact on the disease has not been clear and any potential role of mitochondrial genetics in cancer has been broadly overlooked. To better understand the role of mtDNA in cancer we repurposed targeted clinical sequencing data to assemble the largest dataset of partially matched tumour-normal mtDNA sequences to date (>40,000 tumours). Using this resource we have defined the pan cancer landscape of mtDNA mutations, demonstrating clear evidence of respiratory complex-specific mutational recurrence and selection alongside the impact of mtDNA mutations on patient survival

Key Publications

Gorelick AN, Kim M, Chatila WK, La K, Hakimi AA, Berger MF, Taylor BS, Gammage PA, Reznik E. Respiratory complex and tissue lineage drive recurrent mutations in tumour mtDNA. Nat Metab. 2021 Apr 8. doi: 10.1038/s42255-021-00378-8

Jackson CB, Turnbull DM, Minczuk M, Gammage PA. Therapeutic Manipulation of mtDNA Heteroplasmy: A Shifting Perspective. Trends in Molecular Medicine. 2020; 26: 698-709

Gammage PA, Frezza C. Mitochondrial DNA: the overlooked oncogenome? BMC Biology. 2019;17:53.

 

Targeting Mitochondria 2021 Congress
October 27-29, 2021
Berlin, Germany & Virtual Congress
www.targeting-mitochondria.com