Clinical Application of Antioxidants to Improve Human Oocyte Mitochondrial Function: Advances and Perspective

MitoThe Scientific Committee of WMS is honored to announce that Dr. Cristina Rodríguez-Varela from Medical Research Institute Hospital La Fe (IIS La Fe) in Valencia, Spain will be joining the Targeting Mitochondria 2021 World Congress, which will be held October 27-29, 2021.

Dr. Rodríguez-Varela will give a presentation on Clinical Application of Antioxidants to Improve Human Oocyte Mitochondrial Function: Advances and Perspective.

Summary of the talkMitochondria are essential organelles in the acquisition of human oocyte competence, as sufficient energy levels are crucial for optimal oocyte maturation, fertilization and subsequent embryo development. In addition, mitochondria constitute the first antioxidant line of defense within the cell, counteracting reactive oxygen species (ROS) derived from its own metabolism. An imbalance between the amount of ROS produced and the capacity of the cell to counteract them leads to oxidative stress, and ultimately to mitochondrial dysfunction. This dysfunction, in turn, impairs cellular functions through reduced ATP output and/or increased oxidative stress. Hence, oxidative stress may be the cause of, or be caused by, mitochondrial dysfunction. Regardless of the origin, this condition gives rise to a vicious cycle with positive feedback, ultimately compromising the overall oocyte quality. Antioxidant therapy has arisen in this context as a new approach aiming to improve human oocyte quality by means of improving, or just protecting, mitochondrial function. In this talk, we will highlight the importance of optimal levels of functional mitochondria in the acquisition of human oocyte competence, and we will give an overview of the main antioxidant supplementation therapies currently under research in our species.

Targeting Mitochondria 2021 Congress
October 27-29, 2021 - Berlin & Virtual Congress
www.targeting-mitochondria.com