Keynote Presentation by Prof. Wallace: A Mitochondrial Etiology of the Common Complex Diseases

Prof. Doug Wallace Targeting mitochondria 2019

The Organizing Committee of Targeting Mitochondria 2019 congress is honoured to announce that Prof. Douglas Wallace will be joining us for our 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.

Prof. Douglas Wallace, Member of the National Academy of Science since 1995, is Professor of Pediatrics, Division of Human Genetics, at the University of Pennsylvania and the founding director of the Center for Mitochondrial and Epigenomic Medicine at the Children's Hospital of Philadelphia. Over the past 45 years Wallace has introduced mitochondrial DNA (mtDNA) genetics into medicine thus founding the field of Mitochondrial Genetic Medicine. In 1975, Wallace and associates showed that genetic factors could be inherited though the cytoplasm with the cytoplasmic transfer of chloramphenicol resistance. In 1980 he demonstrated that the human mtDNA is maternally inherited and in 1988 he was the first to identify an inherited human mtDNA disease, Leber hereditary optic neuropathy (LHON). Since then hundreds of mtDNA variants have been linked to disease, see MITOMAP.org. By surveying mtDNA variation in indigenous populations around the world, Wallace and his associates were able to exploit the maternal transmission of the mtDNA to reconstruct the origin and ancient migrations of women. Subsequent studies revealed that the geographic specificity of mtDNA types was the result of environmental selection and that these “adaptive” mtDNA variants can become maladaptive in new environments generating the common variants of common diseases.

At our 10th Anniversary World Congress on Targeting Mitochondria Prof. Wallace will give a Keynote Presentation titled “A Mitochondrial Etiology of the Common Complex Diseases”.

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

Microbiota-Mitochondria Intertalk: A Dedicated session

Tal-Yardeni-Mitochondria-SpeakersDuring the Targeting Mitochondria, a session will be chaired by Prof. Marvin Edeas, University Paris Descartes, INSERM U1016, France, concerning the hot topics 2019: Microbiota-Mitochondria Intertalk.

Two Talks will be presented during this dedicated session: 

Mitochondria & Microbiota Inter-talk: Gut Microbiota inflence Mitochondria activity in patients
Marvin Edeas, University Paris Descartes, INSERM U1016, France

Host mitochondria influence gut microbiome diversity: A role for ROS
Tal Yardeni,
Children's Hospital of Philadelphia, USA

Summary of Dr. Yardeni's presentation: "Changes in the gut microbiome are linked with the same diseases as those caused by changes in the mitochondrial genome. To investigate why, we tested the gut microbiome community of our mitochondrial mouse models. These studies reveal that the host mitochondrial ROS production influences the gut microbiome community. Our data suggest that mitochondrial function modulates both ROS production and the microbiome, implying that the connection between the gut microbiome and common disease might be due to changes in mitochondrial function."

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

Hotel InterContinental Berlin will held the Targeting Mitochondria 2019 Congress

 Budapester Straße 2, 10787 Berlin, Germany

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RCBRLIN 00131 stairs

 
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Special Rate for Room Booking at Intercontinental Berlin Hotel

The upscale InterContinental® Berlin hotel sits next to leafy Tiergarten Park, pleasant walk from the iconic Brandenburg Gate. Choose an elegant room or spacious suite, swim in the inviting indoor pool and indulge in a treatment at SPA InterContinental. Entertaining clients in style on a dedicated meeting floor or making an impression with a function in the ballroom. After work, sip cocktails in the Marlene Bar and experience gourmet dining in a chic 14th-floor restaurant with panoramic city views.

Targeting Mitochondria Committee offers to the congress attendees a special privileged rate for your booking:

Single Room: 139€ by night
Double Room: 164€ by night
 
These prices include breakfast buffet, and also usage of internet in bedrooms.

Follow this link to book your Hotel

The challenge of qualitative and quantitative assessment of mitochondrial function

Dr. Egbert Mik will overview the perspective related to Mitochondria Evaluation in vitro, in vivo and human

 

Egert Mic Mitochondria 2019 upd

Dr. Egbert Mik from the Department of Anesthesiology, Erasmus MC, University Medical Center Rotterdam, The Netherlands will join the 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019

Dr. Mik will present the last methods (qualitative and quantitative assessment of mitochondrial function) and What we know in 2019 ?

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

Mitochondrial Copper Toxicity with a Focus on Wilson Disease

Hans Zischka Targeting Mitochondria 2019

Prof. Hans Zischka from Institute of Molecular Toxicology and Pharmacology, Germany will present his team's research during the congress and will give a talk entitled "Mitochondrial Copper Toxicity with a Focus on Wilson Disease".

Summary of Talk: Wilson disease (WD) is a hereditary defect in the metabolism of copper. Here, the liver is unable to eliminate excess copper causing its accumulation primarily in liver and brain. In neurons and hepatocytes, a rising copper overload particularly damages their mitochondria. However, sometimes years pass before cell death occurs, suggesting the possible existence of intracellular protective mechanisms that can counteract such mitochondrial poisoning.

Therefore, we examined cell cultures from WD patients but also WD rodent models for their reaction to copper. We observed that the hepatocytes reacted to copper overload with an intensification of the mechanisms that support autophagy. Particularly, the copper-overloaded mitochondria are affected by this process (in this case called mitophagy). However, mitophagy helps only up to a certain level of copper overload and other treatments need to be employed to avoid cell death. Nevertheless, these results demonstrate the potential for cell regeneration resulting from auto-/mitophagy, which could also be relevant for other disorders that arise or are paralleled by cell-toxic metal accumulations.

For more information: https://targeting-mitochondria.com

 

 

Mitochondria, as central regulators of neural stem cell fate

ruth-slack targeting mitochondria 2019The Scientific Committee of WMS is honored to announce that  Dr. Ruth Slacks from University of Ottawa, Canada will be joining us for our 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.

Dr. Slacks will give a presentation entitled "Mitochondria, as central regulators of neural stem cell fate".

For more information: https://targeting-mitochondria.com

The brain MITOxy project : from mitochondria to proteases and reactive species interactome in brain

Dr. Laurent Chatre will  introduce "The brain MITOxy project : from mitochondria to proteases and reactive species interactome in brain".

Laurent-Chatre Targeting Mitochondria 2019

Dr. Laurent Chatre from CNRS, the University of Caen-Normandie, France will join the 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.

Summary of presentation: From brain functions to brain hypoxia, ischemia, inflammation and cancer, Dr. Chatre will discuss their starting brain MITOxy project positioningt he coordination between mitochondria, proteases including serine proteases and the reactive species interactome (RSI)as the key regulator involved in normal and pathological conditions, and to control in the future.

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

 

 

 

Mitochondrial Antioxidant Therapy for Treating Vascular Aging

Douglas-R-Seals Mitochondria-2019

Prof. Seals will give a strategic talk on "Mitochondrial Antioxidant Therapy for Treating Vascular Aging".

The Scientific Committee of Targeting Mitochondria 2019 Congress is honored to announce Prof. Douglas R Seals from University of Colorado Boulder, USA will be joining us for our 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.

Summary of the Talk:  Arterial dysfunction is the major risk factor driving the dramatic increase in risk of cardiovascular diseases with aging.  Excessive superoxide production by mitochondria is a key mechanism underlying age-related vascular dysfunction and, as such, is a major therapeutic target for prevention of cardiovascular disorders.  I will discuss our translational research efforts to establish the efficacy of the mitochondrial antioxidant, MitoQ, for the treatment of arterial dysfunction with aging.

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

Increased Hydrogen Peroxide and Decreased Glutathione Redox Potential May Cause Dopaminergic Neurodegeneration in Parkin Loss-of-Function Drosophila

Lori Buhlman Targeting Mitochondria 2019The Scientific Committee of WMS is honored to announce that Dr. Lori Buhlman, Associate Professor from the College of Graduate Studies of Midwestern University, USA, will be joining us for our 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.

In her presentation entitled "Increased Hydrogen Peroxide and Decreased Glutathione Redox Potential May Cause Dopaminergic Neurodegeneration in Parkin Loss-of-Function Drosophila", Dr. Buhlman will discuss with us her recent studies on the mechanism of selective neurodegeneration in familial Parkinson’s disease. They use parkin loss-of-function Drosophila, which have selective dopaminergic neurodegeneration and motor behavior deficits.  "We have observed that degenerating neurons have transiently decreased mitophagy initiation, disrupted mitochondrial dynamics and increased mitochondrial protein oxidation, none of which were detected in non-degenerating dopaminergic neurons. Current goals are to understand important differences between vulnerable and non-degenerating dopaminergic degeneration in adult and developing flies and use genetic and pharmacological interventions to address them."       

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

 

The cellular stress protein MNRR1/CHCHD2 and mitochondrial disease

lawrence-grossman Targeting Mitochondria 2019

Prof. Lawrence Grossman from Wayne State University, USA will join the Targeting Mitochondria 2019 congress and will give a talk entitled "The cellular stress protein MNRR1/CHCHD2 and mitochondrial disease".

Summary of talk: MNRR1 is a key mitochondrial stress regulator with the novel property of functioning in both the nucleus and the mitochondria yet having a different function in each organelle. Because cellular depletion of MNRR1 results in a phenocopy of some mitochondrial diseases, we investigated whether manipulating MNRR1 expression could reverse the cellular defects associated with them. Notably, in a model of the mitochondrial disease MELAS we could restore abnormal cellular functions by forced expression of MNRR1 or by its activation.

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

 

Mitochondrial reactive oxygen species in heart failure

Christoph Maack Mitochondria SpeakerProf. Christoph Maack from University Hospital Würzburg, Germany will join the Targeting Mitochondria 2019 Congress and  present his research work entitled  "Mitochondrial reactive oxygen species in heart failure".

The heart consumes large amounts of energy through the processes of excitation-contraction (EC) coupling in cardiac myocytes. To match energy supply to demand, mitochondria take up Ca2+ via the Ca2+ uniporter (MCU), where Ca2+stimulates rate-limiting enzymes of the Krebs cycle. The main products of the Krebs cycle, NADH and FADH2, donate electrons to the electron transport chain (ETC) to build up the mitochondrial membrane potential (DYm) that is the driving force for ATP production. Furthermore, Ca2+-induced Krebs cycle stimulation also regenerates NADPH for the antioxidative capacity of the mitochondrial matrix. 

Prof. Maack will highlight exactly what we obserse in heart failure during the Targeting Mitochondria Congress.

For more information about Targeting Mitochondria 2019: www.targeting-mitochondria.com

Mitochondria & Microbiota Inter-talk: Gut Microbiota influence Mitochondria activity in patients

Marvin Edeas Mitochondria 2019

During the Targeting Mitochondria, a session will be chaired by Prof. Marvin Edeas, University Paris Descartes, INSERM U1016, France, concerning the hot topics 2019: Microbiota-Mitochondria Intertalk. 

Mitochondria & Microbiota Inter-talk: Gut Microbiota inflence Mitochondria activity in patients
Marvin Edeas, University Paris Descartes, INSERM U1016, France

 

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

T-cell metabolism and mitochondrial function

Alessia Angelin Mitochondria-SpeakersThe Scientific Committee of WMS is honored to announce that Dr. Alessia Angelin from Children's Hospital of Philadelphia, USA will be joining us for our 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.

During the Congress Dr. Angelin will speak about "T-cell metabolism and mitochondrial function".

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

Role of actin-regulating proteins on mitochondria - Introduction by Prof. Cartrsten Culmsee

Culmsee Mitochondria-Speakers

The Scientific Committee of WMS is honored to announce that Prof. Cartrsten Culmsee from University of Marburg, Germany will be joining us for our 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.

During the Congress Prof. Culmsee will introcuce "Role of actin-regulating proteins on mitochondria".

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

Mitochondria and Skin: A dedicated session during Targeting Mitochondria 2019

Sibylle Jager Targeting Mitochondria 2019 CongressDr. Sibylle Jäger from L’Oréal Research & Innovation, France will join the Targeting Mitochondria 2019 Congress and speak about a dedicated session during   "Role of PGC-1s in human epidermal physiology".

During Targeting Mitochondria 2019, a Special session will be dedicated to Mitochondria, Metabolism and Skin. One of the speakers of this session will be Dr. Sibylle Jäge.

She will highlight: "Altered metabolism is a hallmark of aging, and key regulators of metabolism, notably members of the peroxisome proliferator activated receptor gamma coactivator (PGC)-1 family have been implicated in aging and its associated conditions. However, the roles of PGC-1s in skin physiology and aging have been largely unexplored. She investigated the potential role of PGC-1s in skin using human epidermal primary keratinocytes and living epidermal equivalents. Overall, her results show that PGC-1s are essential components of epidermal physiology, revealing a novel axis that could be targeted in skin conditions and aging".

For more information about Targeting Mitochondria 2019: www.targeting-mitochondria.com