Enhanced axonal response of mitochondria to demyelination offers neuroprotection: implications for multiple sclerosis

Mitochondria-Speakers-Don-MahadDr. Don Mahad from University of Edinburgh, United Kingdom,  will join the Targeting Mitochondria 2020 Congress on October 29-30 which will be organized virtually and give a major presentation entitled "Enhanced axonal response of mitochondria to demyelination offers neuroprotection: implications for multiple sclerosis".

Axonal loss is the key pathological substrate of neurological disability in demyelinating disorders, including multiple sclerosis (MS). However, the consequences of demyelination on neuronal and axonal biology are poorly understood. The abundance of mitochondria in demyelinated axons in MS raises the possibility that increased mitochondrial content serves as a compensatory response to demyelination.

Enhancement of ARMD, by targeting mitochondrial biogenesis and mitochondrial transport from the cell body to axon, protects acutely demyelinated axons from degeneration. 

Enhancement of mitochondrial dynamics in complex IV deficient neurons protects the axon upon demyelination. Consequently, increased mobilisation of mitochondria from the neuronal cell body to the axon is a novel neuroprotective strategy for the vulnerable, acutely demyelinated axon. We propose that promoting ARMD is likely to be a crucial preceding step for implementing potential regenerative strategies for demyelinating disorders.

 

Targeting Mitochondria 2020 Congress
October 29-30, 2020
www.targeting-mitochondria.com

Targeting Mitochondria 2020 will organized as VIRTUAL Conference

Dear Colleagues,

After a long and thorough discussion among the scientific and organizing committees, we have decided to organize our 11th Conference of Targeting Mitochondria, on October 29-30, 2020 as an ONLY online meeting.

Targeting Mitochondria 2020 Meeting is not a webinar. All registered attendees will have access to the platform when they wish and at any time.

 

Targeting Mitochondria 2020 Virtual Meeting:
Practical Information


Pre-Recorded Contributions:

Due to restriction and time zone difference, a pre-recorded contribution can be separately viewed online from the date of the conference, October 29, 2020, until November 29th, via the use of access code.


Prior to the Conference:

- All Invited Speakers are being asked to record their 25 minutes talks via the conference platform.

- All Short Oral contributions accepted are being asked to record their 10 minutes talks.

- All Poster contributions accepted are being asked to record their 5 minutes talks and submit the poster in PDF Format.


Conference Platform:

All contributions accepted by the scientific committee will be added to the specific conference platform prior to the conference, as indicated in the session of the program.


How to Access to all Communications (à la Carte):

Upon registration, each pre-recorded contribution can be separately viewed online from the date of the conference, October 29, 2020 until November 29th, via the use of access code. The "à la carte" presentations can be viewed in the comfort of your place.


Awards:

As each year, 3 awards will be given: Best scientific contribution, Best short oral presentation and best poster presentation. The best poster will be selected by the vote of all virtual attendees.

 

Questions, Contact, and Networking:

The conference platform will allow each participant to contact speakers, attendees, and sponsors. If you wish to submit your questions to speakers, you can do it before the meeting.

 

Chairmen and Round Table Discussion:

The Chairmen of each session will record an overview of all talks of their session. You can send also your questions to chairmen.

 

Registration:

We updated the registration fees for this WMS 2020 virtual meeting.

If you wish to cancel your registration, please contact us for reimbursement.

You will receive a refund for the difference in the cost of registration or keep the difference for Targeting Mitochondria 2021 congress.

Please feel free to contact us with any questions you might have.


Best regards,

On behalf of

Prof. Volkmar Weissig

President of the World Mitochondria Society

The Cell-free respiratory Competent Mitochondria in Blood: Strategic Role and Application

Mitochondria-Speakers-Alain-ThierryProf. Alain Thierry from Montpellier Cancer Research Institute, INSERM, France will join the Targeting Mitochondria 2020 Congress which will be organized virtually and give a major presentation entitled "The Cell-free respiratory Competent Mitochondria in Blood: Strategic Role and Application".

The researchers used previous findings which showed that the plasma of a healthy individual contains up to 50,000 times more mitochondrial DNA than nuclear DNA. They hypothesized that for it to be detectable and quantifiable in the blood in this manner, the mitochondrial DNA had to be protected by a structure of sufficient stability. In order to identify such a structure, plasma samples from around 100 individuals were analyzed.

This analysis revealed the presence in the blood circulation of highly stable structures containing whole mitochondrial genomes. Following examination of their size and density, as well as the integrity of their mitochondrial DNA, these structures observed using electron microscopy (up to 3.7 million per ml of plasma) were revealed to be intact and functional mitochondria.

Read the complete news here: A New Blood Component Revealed

Targeting Mitochondria 2020 Congress
October 29-30, 2020
www.targeting-mitochondria.com

Mitochondrial disease community registry (MDCR): Perspectives from patients and families, lessons learned from the data

Mitochondria-Speakers-Sophia-zilberMrs. Sophia Zilber from Boston, USA will join the Targeting Mitchondria 2020 Congress and will give a presentation entitled "Mitochondrial disease community registry (MDCR): Perspectives from patients and families, lessons learned from the data".

Patient-populated registries are an important component of rare disease communities for many reasons, including their use as a tool for gathering opinions on specific topics. The Mitochondrial Disease Community Registry (MDCR) was launched in 2014 by United Mitochondrial Disease Foundation (UMDF) for this purpose as well as to identify and characterize mitochondrial disease patients from the patient perspective. This talk presents data collected over a four year period and provided by adult mitochondrial disease patients and caregivers of pediatric mitochondrial disease patients. Findings suggest the importance of clinician-patient communication, need for treatment and cure, the impact of the disease on the entire life of a person, and quality of life as top issues as described by patients, while also highlighting that patients are hopeful and optimistic.  Additionally, data quality checks showed that more clear and simple questions and shorter more-targeted surveys are needed in order to get accurate and meaningful data for research.

 

Targeting Mitochondria 2020 Congress
October 29-30, 2020
www.targeting-mitochondria.com

Mitochondria Devices: New Methods to Detect Mitochondria Dysfunction

Mitochondria-Speakers-Naig-Gueguen-v3Dr. Naïg Gueguen from  MitoVasc Institute, Angers University Hospital Center, France will give a presentation entitled "Mitochondria Devices: New Methods to Detect Mitochondria Dysfunction" during the Targeting Mitochondria 2020 Congress which will be organized virtually, on October 29-30, 2020.

Alterations in bioenergetics metabolism represent a common clue in the pathogenesis of several diseases, including metabolic disorders, neurodegenerative disease, inflammatory conditions and cancer. Progress toward deciphering the precise role of the mitochondria in disease etiology requires tools and methods that can dissect the complex interplay between multiple enzymes and oxidative pathways that act cooperatively to regenerate ATP and sustain cellular biosynthesis needs. Recent developments in respirometry, coupled to fluorometry/luminescence, allow multiplexing measurements and provide now routine analyses of a variety of processes, including metabolic rewiring, substrate supply pathways, the activities of the different respiratory chain complexes, ATP synthesis or proton leak. In this context, the choice of the relevant experimental model and design are key elements for the identification and quantification of mitochondrial dysfunctions.

Targeting Mitochondria 2020 Congress
October 29-30, 2020 - Berlin, Germany
www.targeting-mitochondria.com

Neurodegeneration and Mitochondria

Mitochondria-Speakers-Ming-Guo

Prof. Ming Guo from UCLA David Geffen School of Medicine, USA will join the Targeting Mitochondria 2020 Congress which will be held in Berlin, Germany on October 29-30, 2020 and present her research during the talk entitled "Neurodegeneration and Mitochondria".

Summary of the Talk: Mitochondrial dysfunction has emerged as a common shared mechanism across multiple neurodegenerative disorders. This includes Parkinson’s disease, myopathy/frontotemporal dementia and ALS. The talk will discuss the latest research regarding these areas. 

 Targeting Mitochondria 2020 Congress
October 29-30, 2020 - Berlin, Germany
www.mitochondria-site.com

Mitochondrial Dysfunction in Autism is Distinct from Mitochondrial Disease

Mitochondria-Speakers-Richard-E.-Frye-v1The Organizing Committee of Targeting Mitochondria 2020 is honored to announce the participation of Prof. Richard E. Frye from Phoenix Children's Hospital, USA.

During the congress, Prof. Frye will give a strategic talk entitled "Mitochondrial Dysfunction in Autism is Distinct from Mitochondrial Disease".

Summary of the talk: Several lines of evidence suggest that mitochondrial function is not normal in many individuals with Autism Spectrum Disorder. However, the patterns of abnormalities found are unlike those seen in classic mitochondrial disease and include unique changes in electron transport chain activity, fatty acid metabolism and regulation of oxidative stress. This talk presents data that suggest that these unique abnormalities are a product of long-term metaplasticity adaptations resulting from exposure to extrinsic or intrinsic physiological stressors such as environmental exposures, microbiome alterations, nutrient deficiencies and/or inflammatory events.

 

Targeting Mitochondria 2020 Congress
October 29-30, 2020 - Berlin, Germany
www.mitochondria-site.com

Down Syndrome: Role of hydrogen sulfide overproduction in the pathogenesis of mitochondrial dysfunction

Mitochondria Speakers Csaba SzaboThe Organizing Committee of Targeting Mitochondria 2020 honored to welcome Prof. Csaba Szabo from the Université de Fribourg, Switzerland.

Prof. Szabo will give a talk entitled "Down Syndrome: Role of hydrogen sulfide overproduction in the pathogenesis of mitochondrial dysfunction" during the congress which will be held on October 29-30, 2020 in Berlin, Germany.

Summary of the talk:  Cystathionine-β-synthase (CBS) is one of the key mammalian enzymes that is responsible for the biological production of the gaseous transmitter hydrogen sulfide (H2S). When H2S is overproduced, it can exert detrimental cellular effects, in part due to inhibition of mitochondrial Complex IV activity. An increased expression of CBS and the consequent overproduction of H2S is well documented in individuals with Down syndrome (DS). Two decades ago, it has been proposed that a toxic overproduction of H2S importantly contributes to the metabolic and neurological deficits associated with DS. However, until recently, this hypothesis has not yet been tested experimentally. The present talk will present recent data generated in human dermal fibroblasts showing that DS cells overproduce H2S, which, in turn, suppresses mitochondrial Complex IV activity and impairs mitochondrial oxygen consumption and ATP generation. Therapeutic CBS inhibition lifts the tonic (and reversible) suppression of Complex IV: this results in the improvement of mitochondrial function in DS cells.

 

Targeting Mitochondria 2020 Congress
October 29-30, 2020 - Berlin, Germany
www.mitochondria-site.com

Submit your Best Mitochondria Image for selection and Win...

BEST-IMAGESSubmit a memorable Mitochondria image you’ve taken this past year and be entered into a drawing for 3 prizes : 

 

- First: 2 nights hotel and free registration at Targeting Mitochondria Meeting in Berlin

- Second: Free Registration 

- Third: One Dinner 
 

Entries must be original. We also accept all Artworks and drawing related to Mitochondria (life, death, energy, dynamics and philosophy...)

 

By submitting your image and caption, you give the WMS permission to include your image (with proper credit being given) into our  2nd edition of MiMB “Mitochondrial Medicine”.

 

To submit, please send us your Mitochondria image + Name and Affiliation to This email address is being protected from spambots. You need JavaScript enabled to view it.

 

 

Prof. Carsten Culmsee, Magburg University, Germany, awarded by the World Mitochondria Society

 Prof. Carsten Culmsee

World MitochondriSociety is honored to announce the winner of the award for his exceptional scientific contribution for the year 2019, Prof. Carsten Culmsee,  from the Magburg University, Germany. 

Prof. Culmsee gave an excellent communication during the 10th World Congress on Targeting Mitochondria 2019, which was held in Berlin, Germany, about the role of actin-regulating proteins on mitochondria

During Targeting Mitochondria 2019, Prof. Culmsee presented new data on the key role of actin-regulating proteins on mitochondrial integrity and function in health and disease of the nervous system and the heart. Also, his talk shows an involvement of mitochondria damage in iron-dependent regulated oxidative cell death called ferroptosis that has been identified in several different organs and tissues, including the nervous system. 

 Carsten Culmsee

For media information: 
Media center: World Mitochondria Society
Contact: www.targeting-mitochondria.com

Keynote Presentation by Prof. Wallace: A Mitochondrial Etiology of the Common Complex Diseases

Prof. Doug Wallace Targeting mitochondria 2019

The Organizing Committee of Targeting Mitochondria 2019 congress is honoured to announce that Prof. Douglas Wallace will be joining us for our 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.

Prof. Douglas Wallace, Member of the National Academy of Science since 1995, is Professor of Pediatrics, Division of Human Genetics, at the University of Pennsylvania and the founding director of the Center for Mitochondrial and Epigenomic Medicine at the Children's Hospital of Philadelphia. Over the past 45 years Wallace has introduced mitochondrial DNA (mtDNA) genetics into medicine thus founding the field of Mitochondrial Genetic Medicine. In 1975, Wallace and associates showed that genetic factors could be inherited though the cytoplasm with the cytoplasmic transfer of chloramphenicol resistance. In 1980 he demonstrated that the human mtDNA is maternally inherited and in 1988 he was the first to identify an inherited human mtDNA disease, Leber hereditary optic neuropathy (LHON). Since then hundreds of mtDNA variants have been linked to disease, see MITOMAP.org. By surveying mtDNA variation in indigenous populations around the world, Wallace and his associates were able to exploit the maternal transmission of the mtDNA to reconstruct the origin and ancient migrations of women. Subsequent studies revealed that the geographic specificity of mtDNA types was the result of environmental selection and that these “adaptive” mtDNA variants can become maladaptive in new environments generating the common variants of common diseases.

At our 10th Anniversary World Congress on Targeting Mitochondria Prof. Wallace will give a Keynote Presentation titled “A Mitochondrial Etiology of the Common Complex Diseases”.

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

Targeting Mitochondria 2019 Congress : Information / Venue / Final Agenda

Please find here all the practical information concerning the Targeting Mitochondria 2019 Congress.

1) Badges & material delivery

The organizing committee will distribute badge and materials Sunday on October 27th, from 17pm to 18:00pm and Monday on October 28th from 7:45 am in the lobby of the Pavillon meeting room.

2) Conference venue

The Congress will be held in the Pavillon meeting room. 

at the InterContinental Berlin Hotel
Budapester Straße 2, 10787 Berlin, Germany
 
If you want to know how to reach the Hotel from Berlin Airport, click here

3) Targeting Mitochondria 2019 Congress Dinner

A dinner is organized on Monday, October 27 at InterContinental Hotel Berlin at 8:30 PM.
If you are not yet registered, Please register here.

4) Who is attending and Networking

In order to organize your planning & meeting with attendees, please find here the list universities and industrials on the site.

5) Certificate of Attendance


The certificate of attendance will be sent to all attendees by email after the Congress.

For all information about activities in Berlin during your stay, please visit the Berlin tourist office here.

6) Final Agenda 

The scientific committee published the final Agenda of Targeting Mitochondria 2019 Congress.


We look forward to meeting you in Berlin and please don't hesitate to contact us for further information.


Targeting-Mitochondria-2019-final-agenda-small

Scientific Agenda

 

Register-here-small

The Short Oral Contribution was discerned to Dr. Jana Schulz

Jana Schulz 1
The Short Oral Contribution Award was discerned to Dr. Jana Schulz from Max Delbrück Center in the Helmholtz Association (MDC), Berlin, Germany, during Targeting Mitochondria 2019, which was held in Berlin, Germany, for her excellent oral presentation entitled "A catalogue of novel mitochondrial microproteins in the human heart".

The presentation of Dr. Schulz concluded that many cardiac long noncoding RNAs (IncRNAs) produce small proteins in vivo and a compelling fraction of which can be associated with the mitochondrion by computational and experimental analyses.

Jana Schulz 2

Jana Schulz

For media information
Media center: World Mitochondria Society
Contact: www.targeting-mitochondria.com

A review paper published by Prof. Weissig, president of the World Mitochondria Society

We are pleased to announce that the review paper of Prof. Weissig, president of WMS, about drug development for mitochondrial diseases, has been recently published online in Trends in Moleculaire Medicine.

Weissig Picture Review

We congratulate Prof. Weissig for his excellent review. 

For more information and access to the review: 
Drug Development for the Therapy of Mitochondrial Diseases
Weissig V. 
Trends Mol Med. 2019, Nov 11
doi.org/10.1016/j.molmed.2019.09.002

"Beautiful anomaly" by Sonja Lehmann

"Beautiful anomaly", submitted by Sonja Lehmann, from the Intitute of Molecular and Cellular Anatomy, in Aachen, Germany, is the second image selected by the Scientific Committee of Targeting Mitochondria 2019 for the 10th anniversary.

4 PC-Keratinocyte MitoTimer SonjaLehmann

Immortalized human keratinocytes derived from patients with the hereditary skin disease Pachyonychia congenita were transfected with MitoTimer. Confocal live-cell imaging revealed the bizarre mitochondrial morphology that rarely occurs in atypical cells.