Final Agenda of Targeting Mitochondria 2019

The scientific committee published the Scientific Agenda of Targeting Mitochondria 2019 Congress.

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Scientific Agenda

Poster submission is open until 15 October.

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Keynote Presentation by Prof. Wallace: A Mitochondrial Etiology of the Common Complex Diseases

Prof. Doug Wallace Targeting mitochondria 2019

The Organizing Committee of Targeting Mitochondria 2019 congress is honoured to announce that Prof. Douglas Wallace will be joining us for our 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.

Prof. Douglas Wallace, Member of the National Academy of Science since 1995, is Professor of Pediatrics, Division of Human Genetics, at the University of Pennsylvania and the founding director of the Center for Mitochondrial and Epigenomic Medicine at the Children's Hospital of Philadelphia. Over the past 45 years Wallace has introduced mitochondrial DNA (mtDNA) genetics into medicine thus founding the field of Mitochondrial Genetic Medicine. In 1975, Wallace and associates showed that genetic factors could be inherited though the cytoplasm with the cytoplasmic transfer of chloramphenicol resistance. In 1980 he demonstrated that the human mtDNA is maternally inherited and in 1988 he was the first to identify an inherited human mtDNA disease, Leber hereditary optic neuropathy (LHON). Since then hundreds of mtDNA variants have been linked to disease, see MITOMAP.org. By surveying mtDNA variation in indigenous populations around the world, Wallace and his associates were able to exploit the maternal transmission of the mtDNA to reconstruct the origin and ancient migrations of women. Subsequent studies revealed that the geographic specificity of mtDNA types was the result of environmental selection and that these “adaptive” mtDNA variants can become maladaptive in new environments generating the common variants of common diseases.

At our 10th Anniversary World Congress on Targeting Mitochondria Prof. Wallace will give a Keynote Presentation titled “A Mitochondrial Etiology of the Common Complex Diseases”.

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

Novel movies showing lipid droplets and mitochondria fine dynamics live and at high resolution

Nanolive video


Thanks to the 3D Cell Explorer’s live imaging capabilities, highlights of lipid droplets and mitochondria fine dynamics that were previously out of reach are clearly visible now.

On the top panel you can observe a time-lapse video of of pre-adipocytes imaged with the 3D Cell Explorer for 1 hour at a frequency of one image per five seconds (movie speed: 15fps). On the middle panel are displayed four time point images of a mitochondrial fission happening in the cell. On the bottom panel a fusion process is displayed.

 

During the Targeting Mitochondria 2019 Congress, Holotomographic Phase Imaging or short Nanolive Imaging will be presented at the Targeting Mitochondria with a talk and booth.

Non-invasive live cell imaging overcomes phototoxicity problem while imaging cellular and mitochondrial processes

Mitochondria are key organelles for various essential cellular processes.

A better understanding of the dynamics and interactions with other organelles could benefit research as well as future therapeutic approaches. The Targeting Mitochondria 2019 will host a broad spectrum of speakers advancing our common scientific field. The introduction of a new technology for label free gentle live cell imaging of Mitochondria might add an important new instrument to this advancement. Holotomographic Phase Imaging or short Nanolive Imaging will be presented at the Targeting Mitochondria with a talk and booth.

A major problem with current imaging techniques is phototoxicity that leads to the observation of perturbed dynamics. Consequently, the mitigation of phototoxicity leads to poor time resolution of time lapse approaches. This is particularly true for small organelles like mitochondria or lipid droplets that are extremely sensitive to photo-induced oxidation. Last but not least, the use of chemical or genetically-encoded fluorescent markers perturbs the targeted biological processes.

However, the Nanolive Imaging allows visualisation of Mitochondria without any staining or labelling. Further, it requireds ~100 times less energy (~0.2 nW/µm2) than light sheet microscopes (~1nW/µm2). With a resolution below 200 nm, it enables high resolution and high-frequency imaging even with sensitive material, giving access to organelle dynamics that were previously out of reach.

Please follow this link to Watch the video.

 

10th Anniversary of Targeting Mitochondria Congress
October 28-29, 2019 - Berlin, Germany
www.mitochondria-site.com

Symposium Actin(g) on mitochondria: The role of actin-regulating proteins on mitochondria in health and disease

Symposium Acting on mitochondria- The role of actin-regulating proteins on mitochondria in health and disease

 

During WMS 2019 Meeting a symposium will be dedicated to Mitochondria Network Consortium on aspects of actin-regulating proteins, regulating mitochondrial function and/or survival signaling, ER-connections and Calcium-signaling in neurons, in the heart and in C. elegans.
 

Culmsee Mitochondria-SpeakersThis symposium will be chaired by Prof. Carsten Culmsee, University of Marburg, Germany.

Introduction: Role of actin-regulating proteins on mitochondria
Cartrsten Culmsee,
University of Marburg, Germany

 

Role of Mitochondria in Ferroptosis
Minghui Gao, University of Harbin, China

Mitochondrial Functions of The Actin-Regulatory Protein Cofilin1
Marco Rust, University of Marburg, Germany

Cofilin Dependent Mitochondrial Dysfunction Following Hemorrhagic Brain Injury and Neuroinflammation
Zahoor Shah, University of Toledo, USA

Mitochondrial Pathways in Neuronal Cell Death
Changlian Zhu, Zhengzhou University, China

Knock-down of ADF/Cofilin in C. Elegans - Effects on Mitochondrial Function

Gunter Eckert, University of Giessen, Germany

Mitochondrial Parameters in Cardiomyocytes in Health and Disease
Christoph Maack, University Hospital Würzburg, Germany

Mitochondrial Calcium Regulation in Hypertensive Heart Disease

Jelena Plakic & Jens Kockskämper, University of Marburg, Germany

Mitochondrial Alterations in Heart Failure

Susanne Rohrbach, University of Giessen, Germany

Blocking Mitochondria-targeted Ferroptosis Prevents Cardiomyopathy

Fudi Wang, University School of Medicine, China

 

10th Anniversary of Targeting Mitochondria Congress
October 28-29, 2019 - Berlin, Germany

Submit your Best Mitochondria Image for selection and Win...

WMS-10-years-anniversaryFor our 10th anniversary, The world Mitochondria Society has launched a call for selecting YOUR BEST Mitochondria IMAGE. 

 

Submit a memorable Mitochondria image you’ve taken this past year and be entered into a drawing for 3 prizes : 

- First : 2 nights hotel and free registration at Targeting Mitochondria Meeting in Berlin

- Second : Free Registration 

- Third : One Dinner 
 

Entries must be original. We also accept all Art works and drawing related to Mitochondria (life, death, energy, dynamics and philosophy...)

 

By submitting your image and caption, you give the WMS permission to include your image (with proper credit being given) into our  2nd edition of MiMB “Mitochondrial Medicine”.

 

To submit, please send us your Mitochondria image + Name and Affiliation to This email address is being protected from spambots. You need JavaScript enabled to view it.

 

 

Cytoskeletal mitochondrial interactions in collagen VI related disorders

Alessia Angelin Mitochondria-SpeakersThe Scientific Committee of WMS is honored to announce that Dr. Alessia Angelin from Children's Hospital of Philadelphia, USA will be joining us for our 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.

During the Congress Dr. Angelin will speak about "Cytoskeletal mitochondrial interactions in collagen VI related disorders".

Summary of presentation:"Mitochondria are prominent players in cell energy conversion, integrated signaling pathways, calcium homeostasis and regulation of apoptosis. Their functional versatility is matched by their morphological plasticity and by their high mobility, allowing their transport to specialized cellular sites. This transport occurs through interactions with a variety of cytoskeletal proteins that also influence shape and function of this organelle. Our study focuses on the correlation between mitochondrial function and cytoskeleton structure. We found that improper cytoskeleton filament organization appears to connect the altered extracellular matrix with the mitochondrial dysfunction in collagen VI related disorders, and thus may present a new target for pharmacological therapy of these disorders and other human muscular dystrophies".

 

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

Microbiota-Mitochondria Intertalk: A Dedicated session

Tal-Yardeni-Mitochondria-SpeakersDuring the Targeting Mitochondria, a session will be chaired by Prof. Marvin Edeas, University Paris Descartes, INSERM U1016, France, concerning the hot topics 2019: Microbiota-Mitochondria Intertalk.

Two Talks will be presented during this dedicated session: 

Mitochondria & Microbiota Inter-talk: Gut Microbiota inflence Mitochondria activity in patients
Marvin Edeas, University Paris Descartes, INSERM U1016, France

Host mitochondria influence gut microbiome diversity: A role for ROS
Tal Yardeni,
Children's Hospital of Philadelphia, USA

Summary of Dr. Yardeni's presentation: "Changes in the gut microbiome are linked with the same diseases as those caused by changes in the mitochondrial genome. To investigate why, we tested the gut microbiome community of our mitochondrial mouse models. These studies reveal that the host mitochondrial ROS production influences the gut microbiome community. Our data suggest that mitochondrial function modulates both ROS production and the microbiome, implying that the connection between the gut microbiome and common disease might be due to changes in mitochondrial function."

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

2,4-Dinitrophenol as Medicine

John Geisle Mitochondria-Speakers-TrameThe Scientific Committee of Targeting Mitochondria 2019 congress invited Dr. John G. Geisler from Mitochon Pharmaceuticals, Inc, USA to talk about his research on "2,4-Dinitrophenol as Medicine" during the 10th Anniversary of Targeting Mitochondria Congress, which will be held in Berlin, Germany, on October 27th – 29th, 2019.

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

 

Targeting Mitochondria 2019 Congress will be held Hotel InterContinental

 Budapester Straße 2, 10787 Berlin, Germany

 *****

RCBRLIN 00131 stairs

 

Hotel Booking with preferential rate is closed after October 7th.

 

 
Please be careful: if some third-party company contacts you Hotel booking & Transport and asks about your Credit card information.
Please book your Hotel only using the special link below!
 
 We do not have any representatives or Travel Agency. If anyone contacts you, it is not related to Targeting Mitochondria 2019 Congress.

Special Rate for Room Booking at Intercontinental Berlin Hotel

The upscale InterContinental® Berlin hotel sits next to leafy Tiergarten Park, pleasant walk from the iconic Brandenburg Gate. Choose an elegant room or spacious suite, swim in the inviting indoor pool and indulge in a treatment at SPA InterContinental. Entertaining clients in style on a dedicated meeting floor or making an impression with a function in the ballroom. After work, sip cocktails in the Marlene Bar and experience gourmet dining in a chic 14th-floor restaurant with panoramic city views.

Targeting Mitochondria Committee offers to the congress attendees a special privileged rate for your booki:

Follow this link to book your Hotel

The challenge of qualitative and quantitative assessment of mitochondrial function

Dr. Egbert Mik will overview the perspective related to Mitochondria Evaluation in vitro, in vivo and human

 

Egert Mic Mitochondria 2019 upd

Dr. Egbert Mik from the Department of Anesthesiology, Erasmus MC, University Medical Center Rotterdam, The Netherlands will join the 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019

Dr. Mik will present the last methods (qualitative and quantitative assessment of mitochondrial function) and What we know in 2019 ?

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

Mitochondrial Copper Toxicity with a Focus on Wilson Disease

Hans Zischka Targeting Mitochondria 2019

Prof. Hans Zischka from Institute of Molecular Toxicology and Pharmacology, Germany will present his team's research during the congress and will give a talk entitled "Mitochondrial Copper Toxicity with a Focus on Wilson Disease".

Summary of Talk: Wilson disease (WD) is a hereditary defect in the metabolism of copper. Here, the liver is unable to eliminate excess copper causing its accumulation primarily in liver and brain. In neurons and hepatocytes, a rising copper overload particularly damages their mitochondria. However, sometimes years pass before cell death occurs, suggesting the possible existence of intracellular protective mechanisms that can counteract such mitochondrial poisoning.

Therefore, we examined cell cultures from WD patients but also WD rodent models for their reaction to copper. We observed that the hepatocytes reacted to copper overload with an intensification of the mechanisms that support autophagy. Particularly, the copper-overloaded mitochondria are affected by this process (in this case called mitophagy). However, mitophagy helps only up to a certain level of copper overload and other treatments need to be employed to avoid cell death. Nevertheless, these results demonstrate the potential for cell regeneration resulting from auto-/mitophagy, which could also be relevant for other disorders that arise or are paralleled by cell-toxic metal accumulations.

For more information: https://targeting-mitochondria.com

 

 

Mitochondria, as central regulators of neural stem cell fate

ruth-slack targeting mitochondria 2019The Scientific Committee of WMS is honored to announce that  Dr. Ruth Slacks from University of Ottawa, Canada will be joining us for our 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.

Dr. Slacks will give a presentation entitled "Mitochondria, as central regulators of neural stem cell fate".

For more information: https://targeting-mitochondria.com

The brain MITOxy project : from mitochondria to proteases and reactive species interactome in brain

Dr. Laurent Chatre will  introduce "The brain MITOxy project : from mitochondria to proteases and reactive species interactome in brain".

Laurent-Chatre Targeting Mitochondria 2019

Dr. Laurent Chatre from CNRS, the University of Caen-Normandie, France will join the 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.

Summary of presentation: From brain functions to brain hypoxia, ischemia, inflammation and cancer, Dr. Chatre will discuss their starting brain MITOxy project positioningt he coordination between mitochondria, proteases including serine proteases and the reactive species interactome (RSI)as the key regulator involved in normal and pathological conditions, and to control in the future.

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

 

 

 

Mitochondrial Antioxidant Therapy for Treating Vascular Aging

Douglas-R-Seals Mitochondria-2019

Prof. Seals will give a strategic talk on "Mitochondrial Antioxidant Therapy for Treating Vascular Aging".

The Scientific Committee of Targeting Mitochondria 2019 Congress is honored to announce Prof. Douglas R Seals from University of Colorado Boulder, USA will be joining us for our 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.

Summary of the Talk:  Arterial dysfunction is the major risk factor driving the dramatic increase in risk of cardiovascular diseases with aging.  Excessive superoxide production by mitochondria is a key mechanism underlying age-related vascular dysfunction and, as such, is a major therapeutic target for prevention of cardiovascular disorders.  I will discuss our translational research efforts to establish the efficacy of the mitochondrial antioxidant, MitoQ, for the treatment of arterial dysfunction with aging.

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com

Increased Hydrogen Peroxide and Decreased Glutathione Redox Potential May Cause Dopaminergic Neurodegeneration in Parkin Loss-of-Function Drosophila

Lori Buhlman Targeting Mitochondria 2019The Scientific Committee of WMS is honored to announce that Dr. Lori Buhlman, Associate Professor from the College of Graduate Studies of Midwestern University, USA, will be joining us for our 10th Anniversary Edition of Targeting Mitochondria World Congress, which will be held in Berlin on October 28th-29th, 2019.

In her presentation entitled "Increased Hydrogen Peroxide and Decreased Glutathione Redox Potential May Cause Dopaminergic Neurodegeneration in Parkin Loss-of-Function Drosophila", Dr. Buhlman will discuss with us her recent studies on the mechanism of selective neurodegeneration in familial Parkinson’s disease. They use parkin loss-of-function Drosophila, which have selective dopaminergic neurodegeneration and motor behavior deficits.  "We have observed that degenerating neurons have transiently decreased mitophagy initiation, disrupted mitochondrial dynamics and increased mitochondrial protein oxidation, none of which were detected in non-degenerating dopaminergic neurons. Current goals are to understand important differences between vulnerable and non-degenerating dopaminergic degeneration in adult and developing flies and use genetic and pharmacological interventions to address them."       

For more information about Targeting Mitochondria 2019: https://targeting-mitochondria.com